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Awarded Trial: 01-005
Grant ID
01-005
Illness
Bipolar II Depression
Primary Drug/Intervention
Lithium
Primary Dosage
according to blood level
Secondary Drug Intervention
Venlafaxine
Secondary Dosage
up to 375 mg
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Amsterdam
Sample Size
84
Duration of Study Period for Each Subject
12 weeks
Outcome Measurements
HAM-D, YMRS
Results
Forty-three patients were randomized to receive venlafaxine monotherapy and forty were randomized to receive lithium monotherapy. Venlafaxine was associated with a larger improvement in depression ratings, a higher proportion of responders (> 50% reduction in HAM-D scores) and a higher proportion of remitters (HAM-D < 8). There was no significant difference between the two days on mania ratings.
Publication
N/A
Link
N/A
PI Name
Jay Amsterdam
Degree
MD
Center
Depression Research Unit
Institution
University of Pennsylvania School of Medicine
Address
3535 Market Street, 3rd Floor
City or Town
Philedelphia
State or Province
PA
Zip or Postal Code
19104
Country
USA
Email Address
jamsterd@mail.med.upenn.edu