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Awarded Trial: 98-RC-325A-2
Grant ID
98-RC-325A-2
Illness
Bipolar Depression
Primary Drug/Intervention
Inositol
Primary Dosage
6-20 gm/day
Secondary Drug Intervention
N/A
Secondary Dosage
N/A
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Sachs
Sample Size
17
Duration of Study Period for Each Subject
6 weeks with 8-week open label extension
Outcome Measurements
HAM-D
Results
Seventeen patients on therapeutic doses of lithium or valproic acid participated. Four of nine subjects on inositol and zero of eight on placebo were responders (> 50% reduction in HAM-D). These results did not reach statistical significance.
Publication
Eden Evins A, Demopulos C, Yovel I, Culhane M, Ogutha J, Grandin LD, Nierenberg AA, Sachs GS. Inositol augmentation of lithium or valproate for bipolar depression. Bipolar Disorders 2006;8:168-174.
Link
http://www.ncbi.nlm.nih.gov/pubmed/16542187
PI Name
Gary Sachs
Degree
MD
Center
Harvard Bipolar Research Program
Institution
Massachusetts General Hospital
Address
50 Staniford St, 5th Floor
City or Town
Boston
State or Province
MA
Zip or Postal Code
2114
Country
USA
Email Address
SachsG@aol.com