Back to Awarded Treatment Trials
Awarded Trial: 00-310
Grant ID
00-310
Illness
Bipolar Disorder
Primary Drug/Intervention
Tamoxifen
Primary Dosage
40 mg
Secondary Drug Intervention
Progesterone
Secondary Dosage
20 mg
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
Kulkarni
Sample Size
21
Duration of Study Period for Each Subject
4 weeks
Outcome Measurements
CARS-M, PANSS, MADRS, AIMS
Results
6 women received tamoxifen and 4 women received progesterone. Patients receiving tamoxifen made a better, faster recovery than those receiving progesterone or placebo. Adequate statistical interpretation of the data could not be achieved due to small sample size.
Publication
Psychoneuroendocrinology. 2006 May;31(4):543-7. Epub 2005 Dec 13. A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder. Kulkarni J1, Garland KA, Scaffidi A, Headey B, Anderson R, de Castella A, Fitzgerald P, Davis SR.
Link
http://www.ncbi.nlm.nih.gov/pubmed/16356651
PI Name
Jayashri Kulkarni
Degree
PhD
Center
Alfred Psychiatry Research Center
Institution
The Alfred Hospital
Address
Level 1, Old Baker Building, P.O. Box 315
City or Town
Prahran
State or Province
Victoria
Zip or Postal Code
3181
Country
Australia
Email Address
jayashri.kulkarni@med.monash.edu.au