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Awarded Trial: BPN-5
Grant ID
BPN-5
Illness
Bipolar Disorder
Primary Drug/Intervention
Topiramate
Primary Dosage
25-600 mg
Secondary Drug Intervention
Sibutramine
Secondary Dosage
5-15 mg
Other Drug/Intervention
N/A
Other Dosage
N/A
Status
Completed
Investigator
McElroy
Sample Size
60
Duration of Study Period for Each Subject
24 weeks
Outcome Measurements
N/A
Results
Forty six patients with bipolar disorder, who had also experienced significant weight gain (>10 pounds since intiation of current psychotropic regimen and a BMI > 30 kg/m2) were randomized to receive adjunctive topiramate or sibutramine for 26 weeks. Subjects receiving topiramate discontinued more often than those receiving sibutramine, but patients receiving topiramate experienced improvements in YMRS and IDS-C scores. Both drugs were associated with significant weight loss.
Publication
McElroy SL, Frye MA, Altshuler LL, Suppes T, Hellemann G, Black D, Mintz J, Kupka R, Nolen W, Leverich GS, Denicoff KD, Post RM, Keck PE Jr. A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorder. Bipolar Disorders 9:426-434, 2007.
Link
http://www.ncbi.nlm.nih.gov/pubmed/17547588
PI Name
Susan McElroy
Degree
MD
Center
N/A
Institution
University of Cincinnati College of Medicine
Address
231 Albert Sabin Way
City or Town
Cincinnati
State or Province
OH
Zip or Postal Code
45267
Country
USA
Email Address
MCELROSL@UCMAIL.UC.EDU